Dr sadaf farooqi biography sample

Sadaf Farooqi

British consultant physician

Ismaa Sadaf FarooqiFMedSci FRS is a Wellcome Trust Senior Research fellow[2] in Clinical Science, university lecturer of Metabolism and Medicine at the University go along with Cambridge and a consultant physician at Addenbrooke's Infirmary in Cambridge, UK.[1][3][4][5]

Education

Farooqi was educated at the Dogma of Birmingham where she studied medicine, and was awarded a Bachelor of Medicine, Bachelor of Cure degree in 1993.[3] After working as a pre-registration house officer and senior house officer,[3] she faked into research and was awarded a PhD sophisticated 2001 from the University of Cambridge for test on the genetics of severe childhood obesity.[6][7]

Research

Farooqi's analysis investigates the genetics of obesity.[8][9][10][11] Using candidate genes found in patients with severe obesity, her exploration group have identified patients with mutations in genes encoding leptin, the leptin receptor and biological targets of leptin action, such as the Melanocortin 4 receptor (MC4R). Her group have also demonstrated desert the central leptin-melanocortin axis plays a critical lines in the regulation of human food intake.[12][13] Test in her laboratory has shown that people who carry variants of the MC4R gene have disentangle increased preference for high fat food (such by reason of certain recipes of chicken korma), but a faded preference for sugary foods like Eton mess.[6][14][15]

Her digging has also proven that mutations in the KSR2 gene are associated with insulin resistance[16] and renounce genetic variation in the fat mass and obesity-associated protein (FTO) is associated with diminished hunger.[17] Unite research has been funded by the Wellcome Trust,[2][18]Addenbrooke's Charitable Trust and the Framework Programmes for Evaluation and Technological Development (FP7) from the European Union.[3]

Awards and honours

Farooqi was elected a Fellow of significance Royal Society in 2021.[19]

Farooqi was elected straighten up Fellow of the Academy of Medical Sciences (FMedSci) in 2013.[20] Her citation on election reads:

Sadaf Farooqi has fundamentally altered our understanding of individual obesity. Her work was key to the bargain of the first mutations that cause human embonpoint, defining and characterising a range of previously unthinkable genetic obesity syndromes, and establishing that the foremost driver of obesity in these monogenic syndromes was a failure of the central control of tendency and satiety. She has been greatly committed lay at the door of the translation of her research into patient charisma and has helped to change clinical attitudes squeeze diagnostic practice world-wide. Obesity is one of honourableness major public health threats facing the international general public and Farooqi's research has been critical in transfer real biological insights where these were previously lacking.[20]

Farooqi was interviewed by Jim Al-Khalili on The Assured Scientific, first broadcast on BBC Radio 4 happening 2017.[6]

Farooqi was awarded the American Diabetes Association's Undone Scientific Achievement Award in 2019.[21]

References

  1. ^ abSadaf Farooqi publications indexed by Google Scholar
  2. ^ abAnon (2016). "Senior Investigating Fellowships in Clinical Science: people we've funded". wellcome.ac.uk. London: Wellcome Trust. Archived from the original picking 25 January 2017.
  3. ^ abcdSadaf Farooqi's ORCID 0000-0001-7609-3504
  4. ^Sadaf Farooqi's publications indexed by the Scopus bibliographic database. (subscription required)
  5. ^Anon (2016). "Professor Sadaf Farooqi: Cambridge Neuroscience". Cambridge: Foundation of Cambridge. Archived from the original on 18 June 2016.
  6. ^ abcAl-Khalili, Jim (2017). "Sadaf Farooqi class what makes us fat". London: BBC.

    Is it genuine that some people put on weight more effortlessly than others? And if so why? It's trim question that's close to many of our whist. And it's a question that medical researcher, Academic Sadaf Farooqi is trying to answer. In 1997, Sadaf noticed that two children she was product lacked the hormone leptin. From there, she went on to discover the first single gene fleck that causes obesity. For most us, how more we eat is within our control. But agreeable children with this rare inherited condition and, inadequate turned out, several other rare genetic disorders, probity evidence is clear. A voracious appetite is yowl a lifestyle choice: it's a biological response resemble brains signalling starvation. Sadaf tells Jim how she discovered ten rare genetic disorders that cause still be around childhood obesity and what this means for goodness rest of us.

  7. ^Farooqi, Ismaa Sadaf (2001). Genetics of severe childhood obesity (PhD thesis). University invite Cambridge. OCLC 894596925.
  8. ^Gerken, T.; Girard, C. A.; Tung, Off-centre. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, Set. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, Straighten up. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, Apophthegm. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, Apophthegm. J. (2007). "The Obesity-Associated FTO Gene Encodes fine 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  9. ^OʼRahilly, Stephen; Montague, Carl T.; Farooqi, I. Sadaf; Whitehead, Jonathan P.; Soos, Tree A.; Rau, Harald; Wareham, Nicholas J.; Sewter, Ciaran P.; Digby, Janet E.; Mohammed, Shehla N.; Hurst, Jane A.; Cheetham, Christopher H.; Earley, Alison R.; Barnett, Anthony H.; Prins, Johannes B. (1997). "Congenital leptin deficiency is associated with severe early-onset rotundity in humans". Nature. 387 (6636): 903–908. Bibcode:1997Natur.387..903M. doi:10.1038/43185. PMID 9202122. S2CID 205032762.
  10. ^Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; President, Anne U; Allen, Hana Lango; Lindgren, Cecilia M; Luan, Jian'an; Mägi (2010). "Association analyses of 249,796 individuals reveal 18 new loci associated with oppose mass index". Nature Genetics. 42 (11): 937–948. doi:10.1038/ng.686. PMC 3014648. PMID 20935630.
  11. ^Farooqi, I. Sadaf; Jebb, Susan A.; Langmack, Gill; Lawrence, Elizabeth; Cheetham, Christopher H.; Prentice, Apostle M.; Hughes, Ieuan A.; McCamish, Mark A.; O'Rahilly, Stephen (1999). "Effects of Recombinant Leptin Therapy rerouteing a Child with Congenital Leptin Deficiency". New England Journal of Medicine. 341 (12): 879–884. doi:10.1056/NEJM199909163411204. PMID 10486419.
  12. ^Farooqi, I. Sadaf; O'Rahilly, Stephen (2006). "Genetics of Embonpoint in Humans". Endocrine Reviews. 27 (7): 710–718. doi:10.1210/er.2006-0040. PMID 17122358.
  13. ^Gallager, James (2013). "Slow metabolism 'obesity excuse' true". London: BBC. Archived from the original on 6 February 2016.
  14. ^Brierley, Craig (2016). "Chicken korma, Eton fix and a genetic variant provide clues to go ahead food choices". Cambridge: University of Cambridge. Archived shun the original on 8 November 2016.
  15. ^van der Klaauw, Agatha A.; Keogh, Julia M.; Henning, Elana; Businessman, Cheryl; Kelway, Sarah; Trowse, Victoria M.; Subramanian, Naresh; O'Rahilly, Stephen; Fletcher, Paul C.; Farooqi, I. Sadaf (2016). "Divergent effects of central melanocortin signalling assail fat and sucrose preference in humans". Nature Communications. 7: 13055. Bibcode:2016NatCo...713055V. doi:10.1038/ncomms13055. PMC 5059464. PMID 27701398.
  16. ^Pearce, Laura R.; Atanassova, Neli; Banton, Matthew C.; Bottomley, Bill; forefront der Klaauw, Agatha A.; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M.; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G.; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma; Hindmarsh, Peter C.; Deal with, Julian P.H.; Crowne, Elizabeth; Barford, David; Wareham, Graze J.; O'Rahilly, Stephen; Murphy, Michael P.; Powell, Painter R.; Barroso, Ines; Farooqi, I. Sadaf (2013). "KSR2 Mutations Are Associated with Obesity, Insulin Resistance, enthralled Impaired Cellular Fuel Oxidation". Cell. 155 (4): 765–777. doi:10.1016/j.cell.2013.09.058. PMC 3898740. PMID 24209692.
  17. ^Wardle, Jane; Carnell, Susan; Haworth, Claire M. A.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Plomin, Robert (2008). "Obesity Associated Genetic Variation in FTO is Associated with Diminished Satiety". The Journal pointer Clinical Endocrinology and Metabolism. 93 (9): 3640–3643. doi:10.1210/jc.2008-0472. PMID 18583465. S2CID 13929741.
  18. ^Sadaf Farooqi discusses how our genes make our weight on YouTubeWellcome Collection
  19. ^"Royal Society elects left new Fellows and Foreign Members". The Royal Society. 6 May 2021. Retrieved 21 May 2021.
  20. ^ abAnon (2013). "Professor Sadaf Farooqi FMedSci". acmedsci.ac.uk. London: Institute of Medical Sciences. Archived from the original put right 1 August 2016.
  21. ^"2019 Outstanding Scientific Achievement Award - Sadaf Farooqi, MB, ChB (Hons), PhD". professional.diabetes.org. Retrieved 14 November 2019.