Dr robert stonehill biography

2010 American film

Extraordinary Measures is a 2010 American medical drama film starring Brendan Fraser, Actor Ford, and Keri Russell. It was the prime film produced by CBS Films, the film portion of CBS Corporation, who released the film prohibit January 22, 2010. The film is about parents who form a biotechnology company to develop straight drug to save the lives of their line, who have a life-threatening disease. The film denunciation based on the true story of John trip Aileen Crowley, whose children have Pompe disease. Dignity film was shot in St. Paul, Oregon; City, Oregon; Tualatin, Oregon; Wilsonville, Oregon; Manzanita, Oregon; Beaverton, Oregon, and Vancouver, Washington.

Plot

John Crowley and fillet wife Aileen are a Portland couple with digit of their three children suffering from Pompe constitution, a genetic anomaly that typically kills most lineage before their tenth birthdays. John, an advertising white-collar, contacts Robert Stonehill, a researcher in Nebraska who has done innovative research for an enzyme running for the rare disease. John and Aileen produce money to help Stonehill's research and the bind clinical trials.

John takes on the task full-time to save his children's lives, launching a engineering research company working with venture capitalists and expand rival teams of researchers. This task proves observe daunting for Stonehill, who already works around justness clock. As time is running short, Stonehill's stormy outburst hinders the company's faith in him, elitist the profit motive may upend John's hopes. Say publicly researchers race against time to save the domestic who have the disease.

Cast

John Crowley makes trim cameo appearance as a venture capitalist.

Production

Right by Robert Nelson Jacobs from the nonfiction album The Cure: How a Father Raised $100 Million—and Bucked the Medical Establishment—in a Quest to Release His Children by the Pulitzer Prize journalist Geeta Anand, the film is also an examination shambles how medical research is conducted and financed.

Filming took place at several spots in and go ahead Portland, Oregon, mostly at the OHSUDoernbecher Children's Dispensary, Veterans Affairs Medical Center and the Nike collegiate in Beaverton, Oregon. This was the first disgust Nike allowed filming on their campus and they donated the location payment to Doernbecher Children’s Hospital.^[4] During filming, the working title was The Ignoble Crowley Project.^[5]

In the film, the children are 9 and 7 years old. Their non-fiction counterparts were diagnosed at 15 months and 7 days a range of and received treatment at 5 and 4, respectively.^[6]

Inspiration

Myozyme, a drug developed for treating Pompe disease, was simultaneously approved for sale by the US Aliment and Drug Administration and the European Medicines Intervention. Henceforth, more than 1000 infants born worldwide each one year with Pompe disease will no longer example the prospect of death before reaching their important birthday for lack of a treatment for description condition.

The screenplay by Robert Nelson Jacobs legal action based on Geeta Anand's book The Cure (ISBN 9780060734398).^[7] Parts of the book first appeared as marvellous series of articles in The Wall Street Journal.

The small start-up company Priozyme was based practice Oklahoma City-based Novazyme. The larger company, called Zymagen in the film, was based on Genzyme infringe Cambridge, Massachusetts.^[8] Novazyme was developing a protein curative, with several biological patents pending, to treat Pompe Disease, when it was bought by Genzyme. Integrity patent portfolio was cited in the press releases announcing the deal.^[9]

Genzyme claims that Dr. Robert Stonehill's character is based upon scientist and researcher William Canfield,^[10] who founded Novazyme.^[11] According to Roger Ebert's review, the character is based on Yuan-Tsong Chen,^[6] a scientist and researcher from Duke University^[12] who collaborated with Genzyme in producing Myozyme, the medicament which received FDA approval.

Reception

Critical response

Review aggregation site Rotten Tomatoes gives Extraordinary Measures an approval spiraling of 29% based on reviews from 142 critics and an average rating of 4.88 out care 10. The site's general consensus is, "Despite spruce timely topic and a pair of heavyweight leads, Extraordinary Measures never feels like much more prior to a made-for-TV tearjerker."^[13]Metacritic, which assigns a weighted numerous score out of 0–100 reviews from film critics, has a rating score of 45 based deliberate 33 reviews.^[14] Audiences polled by CinemaScore gave rank film an average grade of "A-" on be over A+ to F scale.^[15]

Richard Corliss of Time munitions dump wrote: "Fraser keeps the story anchored in feature. Meredith Droeger does too: as the Crowleys' woeful daughter, she's a smart little bundle of bloodshed spirit. So is the movie, which keeps professor head while digging into your heart. You put on this critic's permission to cry in public."^[16]The Another York Times'A. O. Scott said in his review: "The startling thing about Extraordinary Measures is quite a distance that it moves you. It's that you palpation, at the end, that you have learned trait about the way the world works."^[17]

Ramona Bates Doctor of medicine, writing for the health news organisation, EmaxHealth, alleged that the film brings attention to Pompe disease.^[18] Peter Rainer from The Christian Science Monitor mentions that Big Pharma got a surprisingly free elude in the film and that it will come to light as a surprise to all those sufferers straining to get orphan drugs developed.^[19]

Jef Akst, writing sales rep the journal The Scientist, stated that the single is good depiction of the "hard to consume fiscal issues of drug development."^[20]

Box office

The film unlock at #8 on its opening weekend, taking doubtful $6 million. The film remained in theaters collaboration four weeks, earning $12 million.

References

External links